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Brugada Syndrome.
Brugada R, Campuzano O, Sarquella-Brugada G, Brugada P, Brugada J, Hong K. Brugada R, et al. 2005 Mar 31 [updated 2022 Aug 25]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2005 Mar 31 [updated 2022 Aug 25]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301690 Free Books & Documents. Review.
During surgery and in the postsurgical recovery period persons with Brugada syndrome should be monitored by EKG. Prevention of primary manifestations: Quinidine (1-2 g daily). Treatment of asymptomatic individuals is controversial. ...Agents/circumstances to avoid: High fe …
During surgery and in the postsurgical recovery period persons with Brugada syndrome should be monitored by EKG. Prevention of primary manif …
Trafficking and Function of the Voltage-Gated Sodium Channel beta2 Subunit.
Cortada E, Brugada R, Verges M. Cortada E, et al. Biomolecules. 2019 Oct 13;9(10):604. doi: 10.3390/biom9100604. Biomolecules. 2019. PMID: 31614896 Free PMC article. Review.
The voltage-gated sodium channel is vital for cardiomyocyte function, and consists of a protein complex containing a pore-forming alpha subunit and two associated beta subunits. A fundamental, yet unsolved, question is to de …
The voltage-gated sodium channel is vital for cardiomyocyte function, and consists of a protein complex c …
Biophysical Investigation of Sodium Channel Interaction with beta-Subunit Variants Associated with Arrhythmias.
Llongueras JP, Das S, De Waele J, Capulzini L, Sorgente A, Van Petegem F, Bosmans F. Llongueras JP, et al. Bioelectricity. 2020 Sep 1;2(3):269-278. doi: 10.1089/bioe.2020.0030. Epub 2020 Sep 16. Bioelectricity. 2020. PMID: 34476357 Free PMC article.
Background: Voltage-gated sodium (Na(V)) channels help regulate electrical activity of the plasma membrane. Mutations in associated subunits can result in pathological outcomes. Here we examined the interaction of Na(V) channels with card …
Background: Voltage-gated sodium (Na(V)) channels help regulate electrical activity of the plasma membrane. Muta …
The voltage-gated sodium channel beta2 subunit associates with lipid rafts by S-palmitoylation.
Cortada E, Serradesanferm R, Brugada R, Verges M. Cortada E, et al. J Cell Sci. 2021 Mar 26;134(6):jcs252189. doi: 10.1242/jcs.252189. J Cell Sci. 2021. PMID: 33602743
The voltage-gated sodium channel is critical for cardiomyocyte function. It consists of a protein complex comprising a pore-forming alpha subunit and associated beta subunits. ...
The voltage-gated sodium channel is critical for cardiomyocyte function. It consists of a protein complex …
Structures of human Na(v)1.7 channel in complex with auxiliary subunits and animal toxins.
Shen H, Liu D, Wu K, Lei J, Yan N. Shen H, et al. Science. 2019 Mar 22;363(6433):1303-1308. doi: 10.1126/science.aaw2493. Epub 2019 Feb 14. Science. 2019. PMID: 30765606
Voltage-gated sodium channel Na(v)1.7 represents a promising target for pain relief. Here we report the cryo-electron microscopy structures of the human Na(v)1.7-beta1-beta2 complex bound to two combinations of pore blockers and gating modifier toxins …
Voltage-gated sodium channel Na(v)1.7 represents a promising target for pain relief. Here we report the cryo-ele …
Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2.
XiYang YB, Wang YC, Zhao Y, Ru J, Lu BT, Zhang YN, Wang NC, Hu WY, Liu J, Yang JW, Wang ZJ, Hao CG, Feng ZT, Xiao ZC, Dong W, Quan XZ, Zhang LF, Wang TH. XiYang YB, et al. Mol Neurobiol. 2016 Mar;53(2):955-967. doi: 10.1007/s12035-014-9048-3. Epub 2015 Jan 10. Mol Neurobiol. 2016. PMID: 25575679
The role of sodium channel voltage-gated beta 2 (SCN2B) in brain aging is largely unknown. ...Together, the present findings indicated that SCN2B could play an important role in the aging-related cognitive deterioration, whi …
The role of sodium channel voltage-gated beta 2 (SCN2B) in brain aging is largely unknown. …
N-Glycosylation of the voltage-gated sodium channel beta2 subunit is required for efficient trafficking of Na(V)1.5/beta2 to the plasma membrane.
Cortada E, Brugada R, Verges M. Cortada E, et al. J Biol Chem. 2019 Nov 1;294(44):16123-16140. doi: 10.1074/jbc.RA119.007903. Epub 2019 Sep 11. J Biol Chem. 2019. PMID: 31511323 Free PMC article.
The voltage-gated sodium channel is critical for cardiomyocyte function and consists of a protein complex comprising a pore-forming alpha subunit and two associated beta subunits. It has been shown previously that the associ …
The voltage-gated sodium channel is critical for cardiomyocyte function and consists of a protein complex …
A missense mutation in the sodium channel beta2 subunit reveals SCN2B as a new candidate gene for Brugada syndrome.
Riuró H, Beltran-Alvarez P, Tarradas A, Selga E, Campuzano O, Vergés M, Pagans S, Iglesias A, Brugada J, Brugada P, Vázquez FM, Pérez GJ, Scornik FS, Brugada R. Riuró H, et al. Hum Mutat. 2013 Jul;34(7):961-6. doi: 10.1002/humu.22328. Epub 2013 Apr 29. Hum Mutat. 2013. PMID: 23559163
A 20%-25% of BrS patients carry genetic defects that cause loss-of-function of the voltage-gated cardiac sodium channel. Thus, 70%-75% of patients remain without a genetic diagnosis. In this work, we identified a novel missense mutation (p.Asp211Gly) i …
A 20%-25% of BrS patients carry genetic defects that cause loss-of-function of the voltage-gated cardiac sodium chan …
Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.
Baum L, Haerian BS, Ng HK, Wong VC, Ng PW, Lui CH, Sin NC, Zhang C, Tomlinson B, Wong GW, Tan HJ, Raymond AA, Mohamed Z, Kwan P. Baum L, et al. Hum Genet. 2014 May;133(5):651-9. doi: 10.1007/s00439-013-1405-1. Epub 2013 Dec 13. Hum Genet. 2014. PMID: 24337656
High-frequency action potentials are mediated by voltage-gated sodium channels, composed of one large alpha subunit and two small beta subunits, encoded mainly by SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B genes in the brain. ... …
High-frequency action potentials are mediated by voltage-gated sodium channels, composed of one large alpha s …
Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.
Bao Y, Willis BC, Frasier CR, Lopez-Santiago LF, Lin X, Ramos-Mondragón R, Auerbach DS, Chen C, Wang Z, Anumonwo J, Valdivia HH, Delmar M, Jalife J, Isom LL. Bao Y, et al. Circ Arrhythm Electrophysiol. 2016 Dec;9(12):e003923. doi: 10.1161/CIRCEP.116.003923. Circ Arrhythm Electrophysiol. 2016. PMID: 27932425 Free PMC article.
BACKGROUND: Mutations in SCN2B, encoding voltage-gated sodium channel beta2-subunits, are associated with human cardiac arrhythmias, including atrial fibrillation and Brugada syndrome. ...Functional reentry, resulting from the interplay b …
BACKGROUND: Mutations in SCN2B, encoding voltage-gated sodium channel beta2-subunits, are associat …
52 results